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Several studies have reported a prevalence of asthma ranging from 20 to 50% in individuals with homozygous (ZZ) and heterozygous (SZ) A1ATD ( It is hypothesized that augmentation therapy could improve inflammation, reduce bronchial hyperresponsiveness, and prevent the development of chronic airway changes in these patients

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2013, doi: 10.1056/NEJMoa1215740