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Inducers of CYP3A4 The concomitant use of Oxycodone and Acetaminophen Tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to Oxycodone and Acetaminophen Tablets [see WARNINGS]

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The study adhered to the principles of the Declaration of Helsinki, and ethical approval was granted by the Ethics Committee of Tehran University of Medical Sciences (Approval ID: IR.TUMS.SPH.REC.1401.283)