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Significantly decreased GSH content in tumor cells in the glutamine-supplemented group correlates with enhanced tumor volume loss.[76] These data suggest that oral glutamine supplementation will enhance the selectivity of antitumor drugs by protecting normal tissues from and possibly sensitizing tumor cells to radiation-induced and chemotherapy treatment-related injury.[77,76] EFFECT OF GLUTAMINE ON METHOTREXATE EFFICACY AND TOXICITY Oral glutamine has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect

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Abbreviations Reactive oxygen species (ROS)