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Therefore, this study proposes the following hypothesis: “Vitamin supplementation in hypothyroid individuals may enhance adrenal function by regulating cortisol and epinephrine levels, reducing the negative effects of hypothyroidism on adrenal responsiveness.” This study aims to evaluate the pathological changes in the adrenal glands induced by hypothyroidism and to explore the potential role of vitamin B12 supplementation on hormonal regulation and histopathological changes in the adrenal glands