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A single unusual case report did describe a life-threatening eosinophilic pneumopericardium effusion (a type of fluid accumulation around the lungs and heart with high eosinophil counts) in an elderly woman who had been concurrently taking high-dose pantothenic acid (vitamin B5 at 300 mg/day) and biotin (10 mg/day) for two months

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Since analysis of the neopterin concentrations is used to monitor mediated immune activation and inflammation status, these data suggested that B vitamin supplementation did not influence the immune system activation status [176]