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The nanoparticles are spherical (∼105 nm, PDI ≈0.21, −28.7 mV) with high entrapment efficiencies (luteolin ∼84%, rosmarinic acid ∼87%, tilianin ∼89%), DL of 8.61%, and sustained release (∼96% over 48 h)

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NAD + -dependent SIRT1 is significantly upregulated in response to oxidative stress, protecting heart from oxidative damage, contributing to retard of aging