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Studies use the combination to examine GH pulse amplitude-dependent IGF-1 production, IGF-1R signalling dynamics, and the downstream consequences of pharmacologically amplified GH pulsatility on target tissue responses — providing a research tool for studying the GH/IGF-1 axis without the confounding cortisol co-secretion that would accompany use of less selective GHRPs

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Furthermore, the key target gene for depression, FA amide hydrolase (FAAH), demonstrates the strongest binding affinity with AdA (168)