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Full article: Involvement of oxidative stress in post-acute sequelae of COVID-19: clinical implications

When it's chronically overloaded—from running, standing for long periods, or even improper footwear—it develops microscopic tears

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LPO is a free radical chain reaction initiated by ferrous iron, which catalyzes the formation of hydroxyl radicals from hydrogen peroxide (Fenton reaction), 41 attacking PUFAs and generating a self-perpetuating cycle that leads to their destruction