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The k cat / K m values of the S586A variant toward tyrosine and DOPA are 600 and 181 s −1 ·mM −1 , which are 2.78- and 1.79-fold higher than the WT enzyme

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CMS later assigned an MUE of 120 units, which created a real problem for practices doing bilateral large-joint injections: an 80 mg dose in each knee totals 160 mg, and claims for 160 units were denied outright for exceeding the cap