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Additionally, inflammation-induced oxidative stress can degrade drugs 70,74,75

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Apart from delivering the Se from the liver to other parts of the body, it also exerts enzymatic antioxidant (peroxidase) activity in plasma, notably against peroxynitrite-mediated oxidation, nitration, and nitrosation (77–79), and against lipid hydroperoxides formed by lipoxygenases and cyclooxygenases, thus protecting circulating lipoproteins (phospholipids) and cholesterol from oxidation (57, 80–82)