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We showed that, on unfurling of the Munc18-1 loop, helix 11 and 12 in domain 3a bind to the central region of the VAMP2 SNARE motif, and validated its functional relevance in reconstituted assays and in living neurons

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A significant decrease was observed in both parameters when GSH was administered ( p = 0.000 and p = 0.000, respectively, when compared to the BEP group)