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Corneal sensitivity measurement Using the Cochet-Bonnet esthesiometer (Luneau Ophtalmologie, Chartres, France), a corneal sensitivity measurement device ( 24 ), corneal sensitivity was measured in rats administered 0.5% tetracaine or 0.4% oxybuprocaine before corneal anesthesia, then after tetracaine or oxybuprocaine application, before therapy application, at 1 min, and with therapy application, at 5-minute intervals until full sensitivity was restored