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Similarly, in vitro experiments indicate that RBP4 promotes the secretion of various proinflammatory factors from ECs, including vascular cell adhesion molecule-1 (VCAM-1), sICAM-1, sE-selectin, monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6), via activation of NADPH oxidase and NF-κB

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