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GIP (secreted by enteroendocrine K cells, which are predominantly located in the duodenum) and GLP-1 (secreted by enteroendocrine L cells, which are located in the distal gut) are rapidly degraded by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4) [1,2,74]

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Similarly, postmortem studies face challenges in reliably documenting the history of inflammation, infections, or other chronic medical conditions