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Other NDs, like Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), corticobasal syndrome (CBS), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP), are less common, while AD, AMD, and PD are more common (3) (Figure 1)

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Experimental data showed that intravenously injected HABN accumulated in tumor cells and tumor-associated myeloid cells, (possibly as a result of the enhanced permeability and retention effect and targeting of CD44, ROS effect) allowing SC144 to act: radicalizing macrophages into the M1 phenotype, inducing killing effect of CD8 + T cells, enhanced PD-L1 expression in tumor cells and inducing immunogenic cell death in vitro