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Each monomer contains three structural domains (Fig

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All forms of B 12 that are absorbed in the blood are transported by transcobalamin-I (TC-I) and transcobalamin-II (TC-II).5 One study observed that AdCbl seems to be the preferred form for binding to TC-II, whereas MeCbl is bound by both TC-II and TC-I.22 Because only TC-II delivers B 12 inside cells, owing to specialized receptors, it appears that the AdCbl form of B 12 may be delivered more efficiently to body cells than the MeCbl form

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