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Another study also reported DMB's ability to attenuate choline diet-enhanced platelet responsiveness and in vivo rate of thrombus formation (81): the direct inhibition of microbial choline TMA lyase activity and the reduction of the proportion of TMA-producing specific bacteria in the intestinal flora

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Recent studies have emphasized the importance of combination therapy, namely, the synergistic action of stem cells and bioactive scaffolds, targeting multifactorial pathological processes (such as oxidative stress, inflammation, ECM degradation, and apoptosis) for comprehensive treatment