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FIGURE 3 More recently, another study proposed the “population asymmetry” or “single-progenitor” model (Clayton et al., 2007), where the epidermal maintenance is achieved long-term through stochastic fate of a single committed keratinocyte progenitor in the basal layer from a pool of relatively fast cycling undifferentiated Krt5 + Krt14 + epidermal SCs (Figure 3B)