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Two studies reported a strong association between increased serum or urinary pentosidine levels and prevalent and incident vertebral fracture in patients with type 2 diabetes, independent of several confounding factors such as levels of glycated albumin, BMD and renal function.61,62 Pentosidine is only one of the several AGEs present in bone matrix

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In addition to intrinsic or extrinsic silenced stem cell activation signals [1], another possibility for decreased hair regeneration might be the degressive ability of self-elimination of damaged mitochondria