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Based primarily on clinical studies, each micromolar increase in serum bilirubin concentration is associated with a substantial decrease in the risks of developing atherosclerosis [73,74], arterial hypertension [75], diabetes mellitus [76], colorectal cancer [77], Crohńs disease [78], systemic lupus erythematosus [79], Fabry disease [80], or schizophrenia [81]

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Keywords: Cardiovascular disease, Endothelial dysfunction, eNOS uncoupling, Oxidative/nitroxidative stress, Peroxynitrite, Nitric oxide, ADMA, Tetrahydrobiopterin, BH 4 Introduction Cardiovascular disease (CVD) is the leading cause of death worldwide, highlighting the need to investigate its molecular mechanisms for effective treatment options