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Because patients with alcoholic liver disease can produce little SAMe, and the existing SAMe is used up rapidly to generate new GSH, SAMe deficiency typically develops in the cells of these patients

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The elevated lung cancer incidence among workers of the Rönnskär smelter in northern Sweden was originally reported in a population-based case–referent study in St Örjan parish in 1978 (Axelson et al., 1978)