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Stinging Nettle’s mechanism(s) of actions include (1) antioxidant characteristics by serving as a superoxide scavenging agent, and/or stimulating the increase in catalase (CAT), superoxide dismutase (SOD), and glutathione along with protecting against lipid peroxidation, and DNA damage [172,173,174], (2) anti-inflammatory properties by inhibiting COX-1 and COX-2, NFkβ signaling pathway, IL-1 and IL-2, interferon (INF), and TNF-α2 [172,173,174], (3) anti-proliferation properties, where stinging nettle inhibits not only the binding of androgens to their transporter proteins [i.e., sex hormone binding globulin (SHBG)], but also their binding to prostate membrane receptors that contribute to the proliferative effects on prostate tissues along with inhibiting the aromatase enzyme (for estrogen biosynthesis), thus altering prostate growth [172,173,174] and, (4) anti-bacterial/viral activities by inhibiting Gram-negative and Gram-positive bacterium and viruses (respiratory syncytial and cytomegalovirus) by its component compounds of alkaloids, flavonoids, phenols, and saponins [173,174,180,181,182]
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Fulfillment Location:UK
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