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Many patients with neurologic signs of vitamin B12 deficiency do not have readily detectable hematological abnormalities, such as megaloblastic anemia (also known as macrocytic anemia) or neutrophils with hypersegmented nuclei (151

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Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks