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ROLE OF VIRUS IN SEVERE NONIMMEDIATE REACTIONS A variety of severe, rare, potentially life-threatening, drug reactions are described, for which recent evidences suggest an intimate relationship with reactivation of specific virus: the DRESS syndrome, the Stevens-Johnson syndrome (SJS) as well as the Toxic epidermal necrolysis (TEN) and transitional forms ( DRESS Syndrome The DRESS syndrome is a drug-induced delayed reaction with an estimated incidence ranging from one case among 1,000 to 10,000 drug exposures (Kardaun et al., 2013)
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Plaque assays BHK-21 cells grown on 24 well cell culture plates were infected with rGETV-HN, rGETV-mCherry, rGETV-EGFP, rSFV-mCherry, rRRV-mCherry or rSINV-BEBV-mCherry for 1 h at 37 °C, washed three times with PBS to remove unbound virions, and then covered with a mixture (1:1) of 2% solution of methylcellulose and 2× DMEM with 4% FBS for 36 h
